Students living in a Saint Mary's University residence building are in self-isolation.
The school says the decision was made "out of an abundance of caution" following two confirmed, but unrelated, cases of COVID-19.
Those living in Rice Residence will stay in quarantine until they get a negative test result.
"Any residents of Loyola Residence who may have spent any extended time in Rice from April 26-May 3 are also being asked to self-isolate until they receive a negative COVID-19 test result," said a statement from SMU.
The university is working with public health officials and says COVID-19 tests are being offered on campus.